Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?
نویسندگان
چکیده
منابع مشابه
The immunoglobulin constant region contributes to affinity and specificity.
A central dogma in immunology is that antibody specificity is solely the result of variable (V)-region interactions with an antigen. However, this view is not tenable in light of numerous reports that constant heavy (C(H)) domains can affect binding affinity and specificity and V-region structure. Kinetic and thermodynamic proof for the occurrence of this phenomenon is now available. C(H)-regio...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1996
ISSN: 0021-9738
DOI: 10.1172/jci119033